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Other evidence shows that low blood levels of folic acid are linked with a higher risk of fatal coronary heart disease and stroke. Diabetes, obesity, heart disease, smoking and chronic fatigue all increase risk.

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Digestive enzyme deficiency can cause digestive glands, such as the pancreas, to be overworked in their efforts to complete the job of digestion. Flavonoids like rutin are thought to enhance the absorption of Vitamin C, and possibly to prolong the effectiveness of it as well. Failure of the heart pump can also result from many other causes such as severe anemia, hyperthyroidism, heart attacks, and arrhythmias of the heart.